U·H·U·R·U LABS / MOD-BIO-01 / GENE SEQUENCING
Reference Loci · 5′ → 3′ Codon Inspector
5 curated genes · NCBI RefSeq · standard genetic code · Phase 1/4
STATUS
● ONLINE
RENDER
WEBGL 2
Curated Genes
SPECIMEN · HBB● LOADED
HBB
β-Hemoglobin
Organism
Homo sapiens
Locus
11p15.4
Length
93 bp
Codons
31
Source
NCBI RefSeq
Abstract
Carries oxygen in red blood cells. A single base change here causes sickle-cell disease.
A single A→T substitution at the sixth codon (GAG → GTG) swaps glutamate for valine. That one change makes hemoglobin molecules clump and red cells crescent into rigid sickles — but it also confers protection against malaria, which is why the mutation persists in regions where malaria is endemic.
Sequence · 93 bp · 5′ → 3′
11p15.4
Annotated Regions
1–3
Start
Methionine — every protein begins here.
16–18
Codon 6 — sickle-cell locus
GAG (glutamate). A→T here gives GTG (valine) and the sickle phenotype.
22–33
α-helix region
These residues form one of the eight helices of the β-globin fold.
Codon · 1 · pos 1
ATG
→
Amino Acid
Methionine
Met · M
Start codon
START codon — every protein begins here.
Double Helix · B-form
Uhuru Insights
Plain-language summary
Phase 2 →
Ask Uhuru what this gene does — in the language you think in.
Mutation impact
Phase 3 →
Edit a single base and see what changes downstream.
Protein simulation
Phase 4 →
Watch what this code might fold into and what it could do.